Authenticity of Ancient-DNA Results: A Statistical Approach
نویسندگان
چکیده
منابع مشابه
Authenticity of ancient-DNA results: a statistical approach.
Although there have been several papers recommending appropriate experimental designs for ancient-DNA studies, there have been few attempts at statistical analysis. We assume that we cannot decide whether a result is authentic simply by examining the sequence (e.g., when working with humans and domestic animals). We use a maximum-likelihood approach to estimate the probability that a positive r...
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Recent advances in high-thoughput DNA sequencing have made genome-scale analyses of genomes of extinct organisms possible. With these new opportunities come new difficulties in assessing the authenticity of the DNA sequences retrieved. We discuss how these difficulties can be addressed, particularly with regard to analyses of the Neandertal genome. We argue that only direct assays of DNA sequen...
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Preserved archeological and paleontological specimens contain genetic information that has the power to elucidate the recent evolutionary history of humans, domesticates, and the pathogens they harbored. In addition, DNA from forensic samples is important in sample identification and crime solving. However, the DNA of both fossil and forensic remains can be heavily degraded through hydrolytic c...
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In the past few years, the number of autosomal DNA sequences from human fossils has grown explosively and numerous partial or complete sequences are available from our closest relatives, Neanderthal and Denisovans. I review commonly used statistical methods applied to these sequences. These methods fall into three broad classes: methods for estimating levels of contamination, descriptive method...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2004
ISSN: 0002-9297
DOI: 10.1086/422826